Substantial growth in the biosensor research has enabled novel, sensitive and point-of-care
diagnosis of human diseases in the last decade. This paper presents an overview of
the research in the field of biosensors that can potentially predict and diagnosis
of common placental pathologies. A survey of biomarkers in maternal circulation and
their characterization methods is presented, including markers of oxidative stress,
angiogenic factors, placental debris, and inflammatory biomarkers that are associated
with various pathophysiological processes in the context of pregnancy complications.
Novel biosensors enabled by microfluidics technology and nanomaterials is then reviewed.
Representative designs of plasmonic and electrochemical biosensors for highly sensitive
and multiplexed detection of biomarkers, as well as on-chip sample preparation and
sensing for automatic biomarker detection are illustrated. New trends in organ-on-a-chip
based placental disease models are highlighted to illustrate the capability of these
in vitro disease models in better understanding the complex pathophysiological processes,
including mass transfer across the placental barrier, oxidative stress, inflammation,
and malaria infection. Biosensor technologies that can be potentially embedded in
the placental models for real time, label-free monitoring of these processes and events
are suggested. Merger of cell culture in microfluidics and biosensing can provide
significant potential for new developments in advanced placental models, and tools
for diagnosis, drug screening and efficacy testing.
Abbreviations:
CSA (chondroitin sulfate A), ELISA (enzyme-linked immunosorbent assay), EV (extracellular vesicle), fnRBC (fetal nucleated red blood cell), GDM (gestational diabetes mellitus), hCG (human chorionic gonadotropin), IE (Plasmodium falciparum-infected erythrocytes), HPLC (high-performance liquid chromatography), IFN (interferon), IUGR (intrauterine growth restriction), MDA (malondialdehyde), NPs (nanoparticles), OS (oxidative stress), PAPP-A (pregnancy-associated plasma protein A), PE (preeclampsia), PlGF (placental growth factor), PM (placental malaria), PP-13 (placental tissue protein 13), QCM (quartz crystal microbalance), sENG (soluble endoglin), sFlt-1 (soluble VEGF receptor - 1), SPR (surface plasmon resonance), SERS (surface-enhanced plasmon resonance), TNF (tumor necrosis factor), TRPS (tunable resistive pulse sensing), VEGF (vascular endothelial growth factor)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: May 20, 2019
Accepted:
May 14,
2019
Received in revised form:
May 13,
2019
Received:
March 22,
2019
Identification
Copyright
© 2019 Elsevier Inc. All rights reserved.
