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Chronodisruption and diet associated with increased cardiometabolic risk in coronary heart disease patients: the cordioprev study

  • JUAN LUIS ROMERO CABRERA
    Correspondence
    Reprint requests: Antonio García Ríos, Hospital Universitario Reina Sofia Unidad de Lipidos y Arteriosclerosis Avda. Menéndez Pidal, s/n. 14004 Córdoba, Spain, Phone: +34-957010947
    Affiliations
    Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain

    CIBEROBN (CIBER in Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain
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  • MARTA GARAULET
    Correspondence
    Reprint requests: Antonio García Ríos, Hospital Universitario Reina Sofia Unidad de Lipidos y Arteriosclerosis Avda. Menéndez Pidal, s/n. 14004 Córdoba, Spain, Phone: +34-957010947
    Affiliations
    Department of Physiology, University of Murcia, Murcia, Spain

    Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, and Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts
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  • JOSÉ JIMÉNEZ TORRES
    Affiliations
    Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain

    CIBEROBN (CIBER in Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain
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  • JUAN FRANCISCO ALCALÁ DÍAZ
    Affiliations
    Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain

    CIBEROBN (CIBER in Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain
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  • GRACIA MARÍA QUINTANA NAVARRO
    Affiliations
    Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain

    CIBEROBN (CIBER in Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain
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  • LAURA MARTIN PIEDRA
    Affiliations
    Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain

    CIBEROBN (CIBER in Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain
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  • JOSÉ DAVID TORRES PEÑA
    Affiliations
    Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain

    CIBEROBN (CIBER in Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain
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  • FERNANDO RODRÍGUEZ CANTALEJO
    Affiliations
    Biochemical Laboratory, Reina Sofia University Hospital, Córdoba, Spain
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  • ORIOL ALBERTO RANGEL-ZUÑIGA
    Affiliations
    Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain

    CIBEROBN (CIBER in Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain
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  • ELENA MARÍA YUBERO-SERRANO
    Affiliations
    Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain

    CIBEROBN (CIBER in Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain
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  • RAÚL M. LUQUE
    Affiliations
    Department of Cell Biology, Physiology and Immunology, Maimonides Biomedical Research Institute of Cordoba (IMIBIC); University of Cordoba; CIBER Physiopathology of Obesity and Nutrition (CIBERobn), Reina Sofia University Hospital (HURS), Córdoba, Spain
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  • JOSÉ M. ORDOVAS
    Affiliations
    Nutrition and Genomics Laboratory, J.M, US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts

    IMDEA Food Institute, Madrid, Spain
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  • JOSÉ LÓPEZ MIRANDA
    Affiliations
    Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain

    CIBEROBN (CIBER in Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain
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  • PABLO PÉREZ MARTÍNEZ
    Affiliations
    Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain

    CIBEROBN (CIBER in Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain
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  • ANTONIO GARCÍA RÍOS
    Affiliations
    Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Cordoba (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain

    CIBEROBN (CIBER in Physiopathology of Obesity and Nutrition), Instituto de Salud Carlos III, Madrid, Spain
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Published:November 06, 2021DOI:https://doi.org/10.1016/j.trsl.2021.11.001
      Individuals with evening chronotypes are prone to suffer chronodisruption and display worse lifestyle habits than morning-types, exhibiting higher cardiovascular diseases (CVD). However, it is unknown whether CVD patients, who are evening chronotypes, have higher cardiometabolic risk than morning-types. This study explored whether individual chronotypes were associated with cardiometabolic risk in patients from the CORDIOPREV study (n = 857). We also investigated whether potential associations were moderated by long-term consumption of two healthy diets (Mediterranean and Low-fat diets). This population was classified into chronotypes using the Morningness-Eveningness Questionnaire. Seven-day daily rhythms in wrist temperature (T), rest-activity (A) and position (P) were recorded in a subset of patients (n = 168), and an integrative variable TAP was determined. Metabolic Syndrome (MetS) was determined at baseline, and metabolic and inflammation markers were measured at baseline and yearly during the 4 years of follow-up. Differences in several lifestyle factors were analyzed according to chronotype. At all times, evening-types had higher triglycerides, C-reactive protein and homocysteine and lower high density lipoprotein cholesterol than morning-types (P < 0.05). Evening-types had a higher prevalence of MetS (OR 1.58 IC 95% [1.10 – 2.28], P = 0.01). Moreover, they were more sedentary, displayed less and delayed physical activity and ate and slept later. In addition, evening-types had lower amplitude, greater fragmentation, lower robustness and less stable circadian pattern at TAP (P < 0.01), all related to a less healthy circadian pattern. In conclusion, evening-types with CVD had higher cardiometabolic risk and less robust circadian-related rhythms than morning-types, regardless of the nutritional intervention.

      Keywords

      Abbreviations:

      BP (blood pressure), CFI (circadian function index), CHD (coronary heart disease), CRP (C-reactive protein), CVD (Cardiovascular disease), FFQ (food-frequency questionnaire), HDL-C (high density lipoprotein cholesterol), IS (interday stability), IV (intraday variability), MEDAS (Mediterranean diet adherence screener), MEQ (morningness-eveningness questionnaire), MetS (Metabolic Syndrome), METs (metabolic equivalents task), MUFA (monounsaturated fatty acid), PUFA (polyunsaturated fatty acid), RA (relative amplitude), SFA (saturated fatty acid), TAP (temperature, activity and position), TG (triglycerides), WC (waist circumference)
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