ABSTRACT
Hypertension (HTN) is a common endpoint for numerous cardiovascular diseases, the
prevalence of which has been quickly increasing due to a wide range of reasons. Previous
research has found that following stress, ELISA and 16S rDNA sequencing indicated
substantial changes in plasma cytokines or hormones, as well as alterations in gut
microbiota in juvenile hypertensive rats. However, it remains still unclear how such
interaction modifications affect microbial populations and organismal function. Stress-related
hormones show a significant drop. Similar to earlier research, the stress group had
dramatically increased release of pro-inflammatory cytokines such as IL-17. Importantly,
a unified collection of tools that allows for deep and comprehensive colonic structural
investigation has been developed. Stress may limit the transition of macrophages (Mφs)
to M1Mφs while increasing the transfer to M2Mφs. Evidence highlighted that tight junction
proteins were decreased along with enhancement in intestinal permeability. Morphological
analysis revealed that the SHR-S group exhibited considerably higher levels of morphological
alterations and fibrosis in colon, heart, and thoracic aorta tissues.Significant improvements
in bacteria linked with short-chain fatty acid synthesis, such as Prevotella and Ruminococcus, were discovered by metagenomic analysis. Adult hypertensive rats are more susceptible
to gut microbiota disruption and fibrosis as a result of mild restraint stress. This
might contribute to some innovative ideas for HTN both treatment and prevention.
Abbreviations:
ACTH (adrenocorticotropic hormone), AFM (atomic force microscopy), Ang II (angiotensin II), α-SMA (α-smooth muscle actin), BP (blood pressure), Col 1 (collagen 1), CORT (corticosterone), ECM (extracellular matrix), FD-4 (4-kDa FITC-dextran), FGF-2 (fibroblast growth factor), GI (gastrointestinal), HPA (hypothalamic-pituitary-adrenal), HTN (hypertension), HTS (high-throughput sequencing), HRP (horseradish peroxidase), KO (KEGG Orthology), IBD (inflammatory bowel disease), IL-6 (interleukin-6), IPP (Image-Pro Plus 6.0 software), LOD (limit of detection), LOWESS (locally weighted scatterplot smoothing), MAP (mean arterial pressure), Mφ (macrophage), MCP (monocyte chemoattractant protein-1), MMP (Matrix metalloproteinase), NE (Norepinephrine), OTUs (Operational taxonomic units), PCoA (principal coordinates analysis), PDGF (platelet-derived growth factor), SBP (systolic blood pressure), SHR (spontaneously hypertensive rats), SNS (sympathetic nervous system), T2D (type 2 diabetes), TEM (Transmission electron microscopy), TJ (tight junctions), TIMP-1 (tissue inhibitor of metalloproteinase-1), TMB (3,3′,5,5′-Tetramethylbenzidine), TNF-α (tumor necrosis factor-α), TTX (tetrodotoxin), Indo (indomethacin), WKY (Wistar Kyoto rats)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: December 21, 2022
Accepted:
October 23,
2022
Received in revised form:
October 2,
2022
Received:
June 25,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Inc. All rights reserved.
